Drug interactions
Dexmedetomidine + Givinostat
Severity: Major
Dexmedetomidine and Givinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may raise the risk of torsades de pointes. Dexmedetomidine also causes bradycardia, which adds to arrhythmic risk.
What this interaction means in plain words
Dexmedetomidine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexmedetomidine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Additive QT prolongation, with bradycardia from dexmedetomidine as a further risk factor.
What to do
Obtain a baseline ECG and repeat during co-use, correcting potassium and magnesium. Withhold givinostat if QTc becomes markedly prolonged or rises substantially from baseline.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dexmedetomidine
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Dexmedetomidine with Givinostat?
MediHelp rates the interaction as major. Dexmedetomidine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, so combined use may raise the risk of torsades de pointes. Dexmedetomidine also causes bradycardia, which adds to arrhythmic risk.
How serious is the interaction between Dexmedetomidine and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat during co-use, correcting potassium and magnesium. Withhold givinostat if QTc becomes markedly prolonged or rises substantially from baseline.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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