Drug interactions
Dextroamphetamine + Droxidopa
Severity: Moderate
Dextroamphetamine and Droxidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droxidopa is converted to norepinephrine and raises blood pressure, and amphetamine adds indirect sympathomimetic pressor activity. Combined use can increase supine hypertension and heart rate.
What this interaction means in plain words
Dextroamphetamine and Droxidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Droxidopa belongs to Cardiovascular.
Why it happens
Additive pressor effects from norepinephrine formed from droxidopa and amphetamine-induced norepinephrine release.
What to do
Monitor supine and standing blood pressure regularly and elevate the head of the bed during rest. Reduce or stop droxidopa if supine hypertension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Droxidopa
- Droxidopa + Lisdexamfetamine Major
- Droxidopa + Methamphetamine Major
- Droxidopa + Pseudoephedrine Major
- Adrenaline-articaine + Droxidopa Moderate
- Almotriptan + Droxidopa Moderate
- Caffeine + Droxidopa Moderate
Frequently asked questions
Can I take Dextroamphetamine with Droxidopa?
MediHelp rates the interaction as moderate. Dextroamphetamine and Droxidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droxidopa is converted to norepinephrine and raises blood pressure, and amphetamine adds indirect sympathomimetic pressor activity. Combined use can increase supine hypertension and heart rate.
How serious is the interaction between Dextroamphetamine and Droxidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure regularly and elevate the head of the bed during rest. Reduce or stop droxidopa if supine hypertension persists.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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