Drug interactions
Droxidopa + Methamphetamine
Severity: Major
Droxidopa and Methamphetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droxidopa is converted to norepinephrine and can cause supine hypertension. Methamphetamine adds sympathomimetic pressor effects, so blood pressure may rise excessively with a risk of cardiovascular events.
What this interaction means in plain words
Droxidopa and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Droxidopa belongs to Cardiovascular; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive pressor effects from norepinephrine formed from droxidopa and amphetamine-induced norepinephrine release.
What to do
Avoid the combination where possible. If both are used, monitor supine and standing blood pressure, elevate the head of the bed, and reduce or stop droxidopa if supine hypertension develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Droxidopa
- Droxidopa + Lisdexamfetamine Major
- Droxidopa + Pseudoephedrine Major
- Adrenaline-articaine + Droxidopa Moderate
- Almotriptan + Droxidopa Moderate
- Caffeine + Droxidopa Moderate
- Carbidopa-entacapone-levodopa + Droxidopa Moderate
Frequently asked questions
Can I take Droxidopa with Methamphetamine?
MediHelp rates the interaction as major. Droxidopa and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droxidopa is converted to norepinephrine and can cause supine hypertension. Methamphetamine adds sympathomimetic pressor effects, so blood pressure may rise excessively with a risk of cardiovascular events.
How serious is the interaction between Droxidopa and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are used, monitor supine and standing blood pressure, elevate the head of the bed, and reduce or stop droxidopa if supine hypertension develops.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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