Drug interactions
Dextroamphetamine + Hydrocodone
Severity: Moderate
Dextroamphetamine and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic monoamines and, with opioids, may contribute to serotonin toxicity. Amphetamine may also partly offset opioid sedation while masking impairment.
What this interaction means in plain words
Dextroamphetamine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
Amphetamine-induced monoamine release adds to opioid serotonergic activity.
What to do
Monitor for signs of serotonin syndrome and cardiovascular effects during initiation and dose changes. Counsel the patient not to judge impairment by alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Hydrocodone?
MediHelp rates the interaction as moderate. Dextroamphetamine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase synaptic monoamines and, with opioids, may contribute to serotonin toxicity. Amphetamine may also partly offset opioid sedation while masking impairment.
How serious is the interaction between Dextroamphetamine and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome and cardiovascular effects during initiation and dose changes. Counsel the patient not to judge impairment by alertness.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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