Drug interactions
Dextroamphetamine + Imatinib
Severity: Minor
Dextroamphetamine and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 to some extent, and amphetamines are partly metabolised by this enzyme, so exposure to dextroamphetamine could rise modestly. Clinical significance is likely small and is predicted rather than demonstrated.
What this interaction means in plain words
Dextroamphetamine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6-mediated dextroamphetamine metabolism by imatinib.
What to do
No empirical dose change is required; monitor for exaggerated stimulant effects such as tachycardia, hypertension or agitation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Dextroamphetamine with Imatinib?
MediHelp rates the interaction as minor. Dextroamphetamine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6 to some extent, and amphetamines are partly metabolised by this enzyme, so exposure to dextroamphetamine could rise modestly. Clinical significance is likely small and is predicted rather than demonstrated.
How serious is the interaction between Dextroamphetamine and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required; monitor for exaggerated stimulant effects such as tachycardia, hypertension or agitation.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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