Drug interactions
Dextroamphetamine + Ipratropium-salbutamol
Severity: Moderate
Dextroamphetamine and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is a sympathomimetic, and combining it with salbutamol can add to tachycardia, palpitations, tremor, anxiety and blood pressure elevation. The effect is greater with high-dose or nebulized salbutamol and in patients with cardiovascular disease.
What this interaction means in plain words
Dextroamphetamine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive sympathomimetic stimulation through direct beta-agonism and amphetamine-induced catecholamine release.
What to do
Monitor heart rate and blood pressure and ask about palpitations or tremor. Limit salbutamol to the lowest effective dose in patients with cardiac disease or hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Dextroamphetamine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine is a sympathomimetic, and combining it with salbutamol can add to tachycardia, palpitations, tremor, anxiety and blood pressure elevation. The effect is greater with high-dose or nebulized salbutamol and in patients with cardiovascular disease.
How serious is the interaction between Dextroamphetamine and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and ask about palpitations or tremor. Limit salbutamol to the lowest effective dose in patients with cardiac disease or hypertension.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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