Drug interactions
Dextroamphetamine + Milnacipran
Severity: Moderate
Dextroamphetamine and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine releases monoamines including serotonin, and with milnacipran it may increase the risk of serotonin syndrome. Additive noradrenergic effects can also raise blood pressure and heart rate.
What this interaction means in plain words
Dextroamphetamine and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Milnacipran belongs to Central Nervous System.
Why it happens
Additive serotonergic and noradrenergic effects from amphetamine-induced monoamine release and milnacipran reuptake inhibition.
What to do
Monitor blood pressure, heart rate and signs of serotonin toxicity, particularly after dose changes. Reduce or stop one agent if hypertension or neuromuscular excitability occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Milnacipran?
MediHelp rates the interaction as moderate. Dextroamphetamine and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine releases monoamines including serotonin, and with milnacipran it may increase the risk of serotonin syndrome. Additive noradrenergic effects can also raise blood pressure and heart rate.
How serious is the interaction between Dextroamphetamine and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of serotonin toxicity, particularly after dose changes. Reduce or stop one agent if hypertension or neuromuscular excitability occurs.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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