Drug interactions
Dextroamphetamine + Oxymorphone
Severity: Minor
Dextroamphetamine and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is a stimulant that may partly offset opioid sedation, but it does not reverse opioid-induced respiratory depression. The combined effect on alertness is unpredictable, and amphetamines may raise serotonergic or cardiovascular risk.
What this interaction means in plain words
Dextroamphetamine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no consistent pharmacokinetic interaction.
What to do
Do not rely on the stimulant to counter opioid sedation; monitor respiratory status and blood pressure and titrate the opioid by effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Oxymorphone?
MediHelp rates the interaction as minor. Dextroamphetamine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dextroamphetamine is a stimulant that may partly offset opioid sedation, but it does not reverse opioid-induced respiratory depression. The combined effect on alertness is unpredictable, and amphetamines may raise serotonergic or cardiovascular risk.
How serious is the interaction between Dextroamphetamine and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on the stimulant to counter opioid sedation; monitor respiratory status and blood pressure and titrate the opioid by effect.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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