Drug interactions
Dextroamphetamine + Oxytocin
Severity: Moderate
Dextroamphetamine and Oxytocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxytocin can cause hypotension or tachycardia, and vasopressors or sympathomimetics given with it have been associated with severe hypertension. Amphetamines raise blood pressure, so a hypertensive response is possible in the peripartum setting.
What this interaction means in plain words
Dextroamphetamine and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Oxytocin belongs to Endocrine.
Why it happens
Additive pressor effects of sympathomimetic stimulation and oxytocin-related vascular effects.
What to do
Monitor blood pressure and heart rate closely during oxytocin administration in patients taking amphetamines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Oxytocin
- Carboprost tromethamine + Oxytocin Major
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
Frequently asked questions
Can I take Dextroamphetamine with Oxytocin?
MediHelp rates the interaction as moderate. Dextroamphetamine and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxytocin can cause hypotension or tachycardia, and vasopressors or sympathomimetics given with it have been associated with severe hypertension. Amphetamines raise blood pressure, so a hypertensive response is possible in the peripartum setting.
How serious is the interaction between Dextroamphetamine and Oxytocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely during oxytocin administration in patients taking amphetamines.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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