Drug interactions
Dextroamphetamine + Propafenone
Severity: Moderate
Dextroamphetamine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6, which contributes to amphetamine metabolism, so dextroamphetamine exposure may rise. This may increase sympathomimetic effects such as tachycardia, hypertension and arrhythmia, which is relevant in patients with cardiac disease.
What this interaction means in plain words
Dextroamphetamine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Propafenone inhibition of CYP2D6-mediated dextroamphetamine metabolism, with opposing cardiovascular pharmacodynamics.
What to do
Monitor heart rate, blood pressure and ECG, and use the lowest effective stimulant dose. Reduce the dextroamphetamine dose if cardiovascular or CNS stimulation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Propafenone?
MediHelp rates the interaction as moderate. Dextroamphetamine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits CYP2D6, which contributes to amphetamine metabolism, so dextroamphetamine exposure may rise. This may increase sympathomimetic effects such as tachycardia, hypertension and arrhythmia, which is relevant in patients with cardiac disease.
How serious is the interaction between Dextroamphetamine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and use the lowest effective stimulant dose. Reduce the dextroamphetamine dose if cardiovascular or CNS stimulation occurs.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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