Drug interactions
Dextroamphetamine + Quetiapine
Severity: Moderate
Dextroamphetamine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks dopamine and serotonin receptors and is sedating, which can oppose the effects of amphetamine, while stimulants may worsen psychosis. Both may increase heart rate or affect QT interval.
What this interaction means in plain words
Dextroamphetamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine receptors and opposing sedative and alerting effects.
What to do
Monitor psychiatric symptoms, sedation and heart rate, and adjust either drug if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Dextroamphetamine with Quetiapine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks dopamine and serotonin receptors and is sedating, which can oppose the effects of amphetamine, while stimulants may worsen psychosis. Both may increase heart rate or affect QT interval.
How serious is the interaction between Dextroamphetamine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms, sedation and heart rate, and adjust either drug if efficacy is lost.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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