Drug interactions
Dextroamphetamine + Ritonavir
Severity: Moderate
Dextroamphetamine and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP2D6, one of the enzymes that helps metabolize amphetamines, and may raise dextroamphetamine exposure. Increased stimulant and cardiovascular effects are possible, and ritonavir's serotonergic and other effects add uncertainty.
What this interaction means in plain words
Dextroamphetamine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibition of CYP2D6-mediated amphetamine metabolism.
What to do
Monitor heart rate, blood pressure and signs of stimulant excess when starting ritonavir. Consider lowering the dextroamphetamine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Ritonavir?
MediHelp rates the interaction as moderate. Dextroamphetamine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir strongly inhibits CYP2D6, one of the enzymes that helps metabolize amphetamines, and may raise dextroamphetamine exposure. Increased stimulant and cardiovascular effects are possible, and ritonavir's serotonergic and other effects add uncertainty.
How serious is the interaction between Dextroamphetamine and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and signs of stimulant excess when starting ritonavir. Consider lowering the dextroamphetamine dose if adverse effects occur.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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