Drug interactions
Dextroamphetamine + Sertraline
Severity: Moderate
Dextroamphetamine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release serotonin and norepinephrine, and combining them with an SSRI can increase the risk of serotonin syndrome. Sertraline may also modestly increase amphetamine exposure via CYP2D6.
What this interaction means in plain words
Dextroamphetamine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive serotonergic activity plus weak CYP2D6 inhibition by sertraline.
What to do
Monitor for agitation, tremor, hyperthermia, tachycardia and diarrhea, and use the lowest effective amphetamine dose. Stop the drugs if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Sertraline?
MediHelp rates the interaction as moderate. Dextroamphetamine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release serotonin and norepinephrine, and combining them with an SSRI can increase the risk of serotonin syndrome. Sertraline may also modestly increase amphetamine exposure via CYP2D6.
How serious is the interaction between Dextroamphetamine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, tachycardia and diarrhea, and use the lowest effective amphetamine dose. Stop the drugs if serotonin syndrome is suspected.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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