Drug interactions
Dextroamphetamine + Sufentanil
Severity: Moderate
Dextroamphetamine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines may partly counter opioid sedation, but they do not reverse respiratory depression. Both drugs affect hemodynamics and the stimulant can mask the degree of opioid-induced sedation.
What this interaction means in plain words
Dextroamphetamine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Opposing CNS effects with possible additive serotonergic and cardiovascular effects; the net interaction is not well established.
What to do
Titrate sufentanil to respiratory rate and effect rather than alertness alone. Monitor respiration, blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Dextroamphetamine with Sufentanil?
MediHelp rates the interaction as moderate. Dextroamphetamine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines may partly counter opioid sedation, but they do not reverse respiratory depression. Both drugs affect hemodynamics and the stimulant can mask the degree of opioid-induced sedation.
How serious is the interaction between Dextroamphetamine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to respiratory rate and effect rather than alertness alone. Monitor respiration, blood pressure and heart rate.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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