Drug interactions
Dextroamphetamine + Sumatriptan
Severity: Moderate
Dextroamphetamine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release serotonin and norepinephrine, and sumatriptan is a 5-HT1B/1D agonist, so the combination may add to serotonergic and blood pressure effects. Serotonin syndrome has been described with triptans plus serotonergic drugs, though risk is low.
What this interaction means in plain words
Dextroamphetamine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic and vasoconstrictive activity.
What to do
Monitor for agitation, tremor, diaphoresis, hyperthermia and raised blood pressure, and counsel the patient to report these symptoms promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Sumatriptan?
MediHelp rates the interaction as moderate. Dextroamphetamine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release serotonin and norepinephrine, and sumatriptan is a 5-HT1B/1D agonist, so the combination may add to serotonergic and blood pressure effects. Serotonin syndrome has been described with triptans plus serotonergic drugs, though risk is low.
How serious is the interaction between Dextroamphetamine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, diaphoresis, hyperthermia and raised blood pressure, and counsel the patient to report these symptoms promptly.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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