Drug interactions
Dextroamphetamine + Ziprasidone
Severity: Moderate
Dextroamphetamine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is sedating and prolongs the QT interval, whereas dextroamphetamine is a stimulant that increases heart rate and blood pressure. The combination may blunt the intended effects of each drug and could add to cardiovascular and arrhythmic risk in susceptible patients.
What this interaction means in plain words
Dextroamphetamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Opposing CNS effects plus additive cardiovascular effects; ziprasidone causes QT prolongation while amphetamine is sympathomimetic.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and monitor heart rate, blood pressure and QTc. Correct potassium and magnesium disturbances and reassess the need for both drugs if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Ziprasidone?
MediHelp rates the interaction as moderate. Dextroamphetamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone is sedating and prolongs the QT interval, whereas dextroamphetamine is a stimulant that increases heart rate and blood pressure. The combination may blunt the intended effects of each drug and could add to cardiovascular and arrhythmic risk in susceptible patients.
How serious is the interaction between Dextroamphetamine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and monitor heart rate, blood pressure and QTc. Correct potassium and magnesium disturbances and reassess the need for both drugs if palpitations or syncope occur.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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