Drug interactions
Dextroamphetamine transdermal + Linezolid
Severity: Contraindicated
Dextroamphetamine transdermal and Linezolid: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibition enhances the norepinephrine releasing effect of amphetamine. This can cause severe hypertension, hyperpyrexia and hypertensive crisis.
What this interaction means in plain words
Dextroamphetamine transdermal and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Linezolid MAO inhibition slows amphetamine metabolism and potentiates monoamine release.
What to do
Do not combine; amphetamine is contraindicated during or within 14 days of MAOI therapy. Choose a non-MAOI antibiotic or hold the amphetamine and monitor blood pressure.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
- Linezolid 600 mg Film-Coated Tablets - SmPC sections 4.3/4.5 (class statement: directly and indirectly acting sympathomimetic agents; "directly and indirectly acting sympathomimetic agents (including the adrenergic bronchodilators, pseudoephedrine and phenylpropanolamine)") — electronic medicines compendium (UK SmPC)
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Linezolid?
MediHelp rates the interaction as contraindicated. Dextroamphetamine transdermal and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibition enhances the norepinephrine releasing effect of amphetamine. This can cause severe hypertension, hyperpyrexia and hypertensive crisis.
How serious is the interaction between Dextroamphetamine transdermal and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; amphetamine is contraindicated during or within 14 days of MAOI therapy. Choose a non-MAOI antibiotic or hold the amphetamine and monitor blood pressure.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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