Drug interactions
Dextroamphetamine transdermal + Naratriptan
Severity: Moderate
Dextroamphetamine transdermal and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release and block reuptake of monoamines including serotonin, and amphetamine labeling warns of serotonin syndrome with serotonergic drugs such as triptans. Amphetamines also raise blood pressure, which may be relevant with vasoconstrictive triptans.
What this interaction means in plain words
Dextroamphetamine transdermal and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from amphetamine-induced monoamine release and triptan receptor agonism.
What to do
Monitor for serotonin syndrome and blood pressure, particularly at initiation and dose increases. Stop the amphetamine and triptan if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Naratriptan?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release and block reuptake of monoamines including serotonin, and amphetamine labeling warns of serotonin syndrome with serotonergic drugs such as triptans. Amphetamines also raise blood pressure, which may be relevant with vasoconstrictive triptans.
How serious is the interaction between Dextroamphetamine transdermal and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and blood pressure, particularly at initiation and dose increases. Stop the amphetamine and triptan if serotonin syndrome occurs.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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