Drug interactions
Dextroamphetamine transdermal + Quinidine
Severity: Moderate
Dextroamphetamine transdermal and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a strong CYP2D6 inhibitor and may increase amphetamine exposure. This raises the risk of adverse effects such as hypertension, tachycardia and serotonin syndrome.
What this interaction means in plain words
Dextroamphetamine transdermal and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinidine inhibits CYP2D6, reducing amphetamine metabolism.
What to do
Start dextroamphetamine at a lower dose and titrate carefully. Monitor for serotonin syndrome and cardiovascular effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Quinidine?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a strong CYP2D6 inhibitor and may increase amphetamine exposure. This raises the risk of adverse effects such as hypertension, tachycardia and serotonin syndrome.
How serious is the interaction between Dextroamphetamine transdermal and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dextroamphetamine at a lower dose and titrate carefully. Monitor for serotonin syndrome and cardiovascular effects.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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