Drug interactions
Dextroamphetamine transdermal + Sertraline
Severity: Moderate
Dextroamphetamine transdermal and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic monoamines including serotonin, and combined use with an SSRI can lead to serotonin syndrome. Sertraline may also modestly raise amphetamine exposure through CYP2D6 inhibition.
What this interaction means in plain words
Dextroamphetamine transdermal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with possible mild CYP2D6 inhibition.
What to do
Start at a low dose and titrate slowly, monitoring for agitation, tremor, hyperthermia, diarrhea and tachycardia. Remove the patch and stop serotonergic drugs if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Sertraline?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase synaptic monoamines including serotonin, and combined use with an SSRI can lead to serotonin syndrome. Sertraline may also modestly raise amphetamine exposure through CYP2D6 inhibition.
How serious is the interaction between Dextroamphetamine transdermal and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at a low dose and titrate slowly, monitoring for agitation, tremor, hyperthermia, diarrhea and tachycardia. Remove the patch and stop serotonergic drugs if serotonin syndrome develops.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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