Drug interactions
Dextroamphetamine transdermal + Sumatriptan
Severity: Moderate
Dextroamphetamine transdermal and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release monoamines including serotonin, and combining them with a triptan may increase the chance of serotonin syndrome. Amphetamines can also raise blood pressure, which may be unwelcome alongside triptan vasoconstriction.
What this interaction means in plain words
Dextroamphetamine transdermal and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from amphetamine-induced monoamine release and triptan 5-HT1 agonism.
What to do
Monitor for serotonin syndrome, especially when starting or increasing doses. Stop the serotonergic agents if it occurs, and check blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Sumatriptan?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release monoamines including serotonin, and combining them with a triptan may increase the chance of serotonin syndrome. Amphetamines can also raise blood pressure, which may be unwelcome alongside triptan vasoconstriction.
How serious is the interaction between Dextroamphetamine transdermal and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, especially when starting or increasing doses. Stop the serotonergic agents if it occurs, and check blood pressure.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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