Drug interactions
Dextroamphetamine transdermal + Terbinafine
Severity: Moderate
Dextroamphetamine transdermal and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is partly metabolized by CYP2D6, and terbinafine may raise its levels. Higher exposure increases stimulant effects and the risk of serotonin syndrome.
What this interaction means in plain words
Dextroamphetamine transdermal and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Terbinafine inhibits CYP2D6, reducing amphetamine metabolism and raising plasma concentrations.
What to do
Start with lower doses and monitor for agitation, tachycardia and signs of serotonin syndrome; stop the patch if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Dextroamphetamine transdermal with Terbinafine?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine is partly metabolized by CYP2D6, and terbinafine may raise its levels. Higher exposure increases stimulant effects and the risk of serotonin syndrome.
How serious is the interaction between Dextroamphetamine transdermal and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses and monitor for agitation, tachycardia and signs of serotonin syndrome; stop the patch if serotonin syndrome occurs.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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