Drug interactions
Dextroamphetamine transdermal + Tranylcypromine
Severity: Contraindicated
Dextroamphetamine transdermal and Tranylcypromine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines cause large releases of norepinephrine and dopamine, and MAO inhibition makes this release far more potent. This can produce hypertensive crisis, hyperpyrexia and cerebrovascular events.
What this interaction means in plain words
Dextroamphetamine transdermal and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Enhanced monoamine release with blocked MAO-mediated degradation produces an exaggerated adrenergic response.
What to do
Do not use during or within 14 days after stopping tranylcypromine. Choose an alternative treatment that does not involve sympathomimetics.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Dextroamphetamine transdermal and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amphetamines cause large releases of norepinephrine and dopamine, and MAO inhibition makes this release far more potent. This can produce hypertensive crisis, hyperpyrexia and cerebrovascular events.
How serious is the interaction between Dextroamphetamine transdermal and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during or within 14 days after stopping tranylcypromine. Choose an alternative treatment that does not involve sympathomimetics.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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