Drug interactions
Dextromethorphan + Lofepramine
Severity: Moderate
Dextromethorphan and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have serotonergic effects, and the combination may increase the risk of serotonin syndrome. Tricyclic metabolism via CYP2D6 may also compete with dextromethorphan.
What this interaction means in plain words
Dextromethorphan and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with possible competition for CYP2D6 metabolism.
What to do
Prefer a non-serotonergic antitussive. If both are used, keep dextromethorphan doses low and monitor for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextromethorphan and Lofepramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Lofepramine?
MediHelp rates the interaction as moderate. Dextromethorphan and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have serotonergic effects, and the combination may increase the risk of serotonin syndrome. Tricyclic metabolism via CYP2D6 may also compete with dextromethorphan.
How serious is the interaction between Dextromethorphan and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic antitussive. If both are used, keep dextromethorphan doses low and monitor for signs of serotonin toxicity.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
