Drug interactions
Dextromethorphan + Lsd
Severity: Major
Dextromethorphan and Lsd: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD acts as a serotonin receptor agonist, and with dextromethorphan it may increase serotonergic toxicity and cause unpredictable psychiatric effects.
What this interaction means in plain words
Dextromethorphan and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity at serotonin receptors and transporters.
What to do
Avoid the combination; manage serotonin toxicity supportively if symptoms arise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Lsd?
MediHelp rates the interaction as major. Dextromethorphan and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. LSD acts as a serotonin receptor agonist, and with dextromethorphan it may increase serotonergic toxicity and cause unpredictable psychiatric effects.
How serious is the interaction between Dextromethorphan and Lsd?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; manage serotonin toxicity supportively if symptoms arise.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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