Drug interactions
Dextromethorphan + Molindone
Severity: Moderate
Dextromethorphan and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromethorphan has serotonergic activity and molindone blocks dopamine receptors, so rare serotonin toxicity or neuroleptic-type reactions are theoretically possible when combined. Clinical evidence is limited to isolated reports for antipsychotics in general.
What this interaction means in plain words
Dextromethorphan and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopaminergic modulation; mechanism not firmly established.
What to do
Monitor for mental status change, hyperthermia, rigidity and autonomic instability when starting or increasing either drug. Stop the agents and treat if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextromethorphan and Molindone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Molindone?
MediHelp rates the interaction as moderate. Dextromethorphan and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextromethorphan has serotonergic activity and molindone blocks dopamine receptors, so rare serotonin toxicity or neuroleptic-type reactions are theoretically possible when combined. Clinical evidence is limited to isolated reports for antipsychotics in general.
How serious is the interaction between Dextromethorphan and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity and autonomic instability when starting or increasing either drug. Stop the agents and treat if serotonin syndrome or NMS is suspected.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
