Drug interactions
Dextromethorphan + Nefazodone
Severity: Moderate
Dextromethorphan and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity and strongly inhibits CYP3A4, a secondary route for dextromethorphan. The combination may increase the risk of serotonin syndrome.
What this interaction means in plain words
Dextromethorphan and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with minor CYP3A4-mediated increase in dextromethorphan exposure.
What to do
Prefer a non-serotonergic antitussive. If both are used, monitor for agitation, tremor, and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Nefazodone?
MediHelp rates the interaction as moderate. Dextromethorphan and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity and strongly inhibits CYP3A4, a secondary route for dextromethorphan. The combination may increase the risk of serotonin syndrome.
How serious is the interaction between Dextromethorphan and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic antitussive. If both are used, monitor for agitation, tremor, and hyperthermia.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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