Drug interactions
Dextromethorphan + Sumatriptan intranasal
Severity: Moderate
Dextromethorphan and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both triptans and dextromethorphan act on serotonin pathways, so combined use might add to serotonin syndrome risk. Clinical cases are rare.
What this interaction means in plain words
Dextromethorphan and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism and serotonin reuptake inhibition.
What to do
Counsel patients on symptoms of serotonin syndrome and stop one agent if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Dextromethorphan and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both triptans and dextromethorphan act on serotonin pathways, so combined use might add to serotonin syndrome risk. Clinical cases are rare.
How serious is the interaction between Dextromethorphan and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on symptoms of serotonin syndrome and stop one agent if they occur.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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