Drug interactions
Dextromethorphan + Thiothixene
Severity: Moderate
Dextromethorphan and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromethorphan has serotonergic activity and thiothixene blocks dopamine receptors, so serotonin toxicity or neuroleptic-type reactions are theoretically possible when combined. Evidence is limited to isolated reports.
What this interaction means in plain words
Dextromethorphan and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopaminergic modulation; mechanism not firmly established.
What to do
Monitor for agitation, hyperthermia, rigidity and autonomic instability when starting or increasing either drug. Stop the agents and treat if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Thiothixene?
MediHelp rates the interaction as moderate. Dextromethorphan and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextromethorphan has serotonergic activity and thiothixene blocks dopamine receptors, so serotonin toxicity or neuroleptic-type reactions are theoretically possible when combined. Evidence is limited to isolated reports.
How serious is the interaction between Dextromethorphan and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, rigidity and autonomic instability when starting or increasing either drug. Stop the agents and treat if serotonin syndrome or NMS is suspected.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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