Drug interactions
Dextromoramide + Methocarbamol
Severity: Major
Dextromoramide and Methocarbamol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid analgesic, and methocarbamol is a centrally acting muscle relaxant with sedative properties. Together they can cause deeper sedation, impaired psychomotor performance and respiratory depression.
What this interaction means in plain words
Dextromoramide and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism plus the central sedative effect of methocarbamol.
What to do
Use the lowest effective doses and avoid the combination in patients with respiratory compromise. Monitor sedation and respiratory rate, especially at initiation or dose increases.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methocarbamol
Frequently asked questions
Can I take Dextromoramide with Methocarbamol?
MediHelp rates the interaction as major. Dextromoramide and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid analgesic, and methocarbamol is a centrally acting muscle relaxant with sedative properties. Together they can cause deeper sedation, impaired psychomotor performance and respiratory depression.
How serious is the interaction between Dextromoramide and Methocarbamol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid the combination in patients with respiratory compromise. Monitor sedation and respiratory rate, especially at initiation or dose increases.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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