Drug interactions
Dextromoramide + Orphenadrin
Severity: Major
Dextromoramide and Orphenadrin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid and orphenadrine adds sedation and anticholinergic effects. The combination may cause profound sedation and respiratory depression.
What this interaction means in plain words
Dextromoramide and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, plus additive antimuscarinic effects.
What to do
Avoid if possible, otherwise use the lowest doses and monitor respiratory rate and sedation. Counsel patients against driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextromoramide and Orphenadrin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Orphenadrin
Frequently asked questions
Can I take Dextromoramide with Orphenadrin?
MediHelp rates the interaction as major. Dextromoramide and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid and orphenadrine adds sedation and anticholinergic effects. The combination may cause profound sedation and respiratory depression.
How serious is the interaction between Dextromoramide and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, otherwise use the lowest doses and monitor respiratory rate and sedation. Counsel patients against driving.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
