Drug interactions
Dextromoramide + Ziprasidone
Severity: Moderate
Dextromoramide and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause deeper sedation, impaired psychomotor performance and respiratory depression. The risk is highest at the start of treatment or after dose increases.
What this interaction means in plain words
Dextromoramide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the opioid agonist and the sedating antipsychotic.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate, especially when starting or titrating either drug. Counsel patients to avoid driving and other alcohol or sedative use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Dextromoramide with Ziprasidone?
MediHelp rates the interaction as moderate. Dextromoramide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause deeper sedation, impaired psychomotor performance and respiratory depression. The risk is highest at the start of treatment or after dose increases.
How serious is the interaction between Dextromoramide and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate, especially when starting or titrating either drug. Counsel patients to avoid driving and other alcohol or sedative use.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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