Drug interactions
DHEA herbal + Lapatinib
Severity: Minor
DHEA herbal and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is not an established CYP3A4 inhibitor, so a claimed rise in lapatinib levels is poorly supported. DHEA also has hormonal activity that may be unsuitable in hormone-sensitive cancers.
What this interaction means in plain words
DHEA herbal and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
A possible CYP3A4 effect has been proposed but is not well established.
What to do
No dose adjustment is needed. Advise against unsupervised DHEA supplements during cancer therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take DHEA herbal with Lapatinib?
MediHelp rates the interaction as minor. DHEA herbal and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA is not an established CYP3A4 inhibitor, so a claimed rise in lapatinib levels is poorly supported. DHEA also has hormonal activity that may be unsuitable in hormone-sensitive cancers.
How serious is the interaction between DHEA herbal and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Advise against unsupervised DHEA supplements during cancer therapy.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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