Drug interactions
Diazepam + Dosulepin
Severity: Moderate
Diazepam and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant and combined use with diazepam increases drowsiness and psychomotor impairment. Overdose toxicity of both drugs is also worsened.
What this interaction means in plain words
Diazepam and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depression through antihistaminic and anticholinergic effects of dosulepin plus benzodiazepine GABA-A potentiation.
What to do
Monitor for oversedation, start with low doses and counsel on driving; limit benzodiazepine duration and avoid in patients at risk of overdose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Diazepam with Dosulepin?
MediHelp rates the interaction as moderate. Diazepam and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant and combined use with diazepam increases drowsiness and psychomotor impairment. Overdose toxicity of both drugs is also worsened.
How serious is the interaction between Diazepam and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, start with low doses and counsel on driving; limit benzodiazepine duration and avoid in patients at risk of overdose.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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