Drug interactions
Diazepam + Doxylamine
Severity: Moderate
Diazepam and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine and adds to diazepam's sedative effect. Excess drowsiness, impaired coordination and next-day impairment may occur.
What this interaction means in plain words
Diazepam and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-antihistamine and benzodiazepine GABA-A effects.
What to do
Avoid concurrent use as a sleep aid with diazepam where possible; if combined, counsel on sedation and avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Doxylamine
Frequently asked questions
Can I take Diazepam with Doxylamine?
MediHelp rates the interaction as moderate. Diazepam and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine and adds to diazepam's sedative effect. Excess drowsiness, impaired coordination and next-day impairment may occur.
How serious is the interaction between Diazepam and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as a sleep aid with diazepam where possible; if combined, counsel on sedation and avoid driving.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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