Drug interactions
Diazepam + Istradefylline
Severity: Minor
Diazepam and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg/day, istradefylline raises exposure to CYP3A4 substrates, which may increase diazepam effects such as sedation. This effect was not seen at 20 mg/day.
What this interaction means in plain words
Diazepam and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent weak inhibition of CYP3A4 by istradefylline.
What to do
Monitor for sedation, especially if istradefylline is at 40 mg/day, and consider reducing the diazepam dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Istradefylline
Frequently asked questions
Can I take Diazepam with Istradefylline?
MediHelp rates the interaction as minor. Diazepam and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg/day, istradefylline raises exposure to CYP3A4 substrates, which may increase diazepam effects such as sedation. This effect was not seen at 20 mg/day.
How serious is the interaction between Diazepam and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, especially if istradefylline is at 40 mg/day, and consider reducing the diazepam dose.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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