Drug interactions
Diazepam + Ivosidenib
Severity: Moderate
Diazepam and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower diazepam concentrations, reducing its anxiolytic, anticonvulsant or sedative effect. The effect is of modest clinical importance for most uses of diazepam.
What this interaction means in plain words
Diazepam and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing diazepam metabolism.
What to do
Monitor for loss of diazepam effect and titrate the dose upward if needed. Consider an alternative benzodiazepine such as lorazepam when seizure control matters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Diazepam with Ivosidenib?
MediHelp rates the interaction as moderate. Diazepam and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower diazepam concentrations, reducing its anxiolytic, anticonvulsant or sedative effect. The effect is of modest clinical importance for most uses of diazepam.
How serious is the interaction between Diazepam and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of diazepam effect and titrate the dose upward if needed. Consider an alternative benzodiazepine such as lorazepam when seizure control matters.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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