Drug interactions
Diazepam + Lofexidine
Severity: Moderate
Diazepam and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a central alpha-2 agonist that causes sedation and hypotension, which add to diazepam's effects. Excess drowsiness, low blood pressure and bradycardia may result.
What this interaction means in plain words
Diazepam and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects from alpha-2 agonism plus GABA-A potentiation.
What to do
Monitor blood pressure, heart rate and sedation, and reduce doses if symptomatic hypotension or oversedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Diazepam with Lofexidine?
MediHelp rates the interaction as moderate. Diazepam and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a central alpha-2 agonist that causes sedation and hypotension, which add to diazepam's effects. Excess drowsiness, low blood pressure and bradycardia may result.
How serious is the interaction between Diazepam and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, and reduce doses if symptomatic hypotension or oversedation develops.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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