Drug interactions
Diazepam + Mavacamten
Severity: Moderate
Diazepam and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is a weak CYP2C19 inhibitor and may increase mavacamten exposure. Higher levels could reduce left ventricular ejection fraction and worsen heart failure symptoms.
What this interaction means in plain words
Diazepam and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Mavacamten belongs to Cardiovascular.
Why it happens
CYP2C19 inhibition reduces mavacamten metabolism.
What to do
Monitor left ventricular ejection fraction and clinical status when starting or stopping diazepam. Adjust mavacamten dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Diazepam with Mavacamten?
MediHelp rates the interaction as moderate. Diazepam and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam is a weak CYP2C19 inhibitor and may increase mavacamten exposure. Higher levels could reduce left ventricular ejection fraction and worsen heart failure symptoms.
How serious is the interaction between Diazepam and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical status when starting or stopping diazepam. Adjust mavacamten dose per labeling.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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