Drug interactions
Diazepam + Miconazole
Severity: Moderate
Diazepam and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is metabolized by CYP3A4 and CYP2C19, and azole inhibitors can raise its levels. Systemic miconazole exposure from vaginal use is low, so the effect is generally modest. Increased levels can cause greater sedation and psychomotor impairment.
What this interaction means in plain words
Diazepam and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4 and CYP2C19, reducing diazepam clearance.
What to do
Warn the patient about increased drowsiness and avoid driving if sedated. Consider a lower diazepam dose in elderly patients or with prolonged miconazole use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Miconazole?
MediHelp rates the interaction as moderate. Diazepam and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam is metabolized by CYP3A4 and CYP2C19, and azole inhibitors can raise its levels. Systemic miconazole exposure from vaginal use is low, so the effect is generally modest. Increased levels can cause greater sedation and psychomotor impairment.
How serious is the interaction between Diazepam and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about increased drowsiness and avoid driving if sedated. Consider a lower diazepam dose in elderly patients or with prolonged miconazole use.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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