Drug interactions
Diazepam + Nifedipine
Severity: Minor
Diazepam and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may slightly raise diazepam levels, and both can cause dizziness or lowered blood pressure. The clinical significance is generally small.
What this interaction means in plain words
Diazepam and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Nifedipine belongs to Cardiovascular.
Why it happens
Possible weak inhibition of CYP3A4-mediated diazepam metabolism, with additive hypotensive and sedative effects.
What to do
No routine dose change is needed; monitor for excess sedation and hypotension, especially at initiation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Nifedipine
Frequently asked questions
Can I take Diazepam with Nifedipine?
MediHelp rates the interaction as minor. Diazepam and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine may slightly raise diazepam levels, and both can cause dizziness or lowered blood pressure. The clinical significance is generally small.
How serious is the interaction between Diazepam and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for excess sedation and hypotension, especially at initiation.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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