Drug interactions
Diazepam + Nilotinib
Severity: Moderate
Diazepam and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may raise diazepam concentrations, causing increased or prolonged sedation. Nilotinib also prolongs the QT interval, but this is not directly affected by diazepam.
What this interaction means in plain words
Diazepam and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Nilotinib is a moderate CYP3A4 inhibitor that reduces diazepam metabolism.
What to do
Monitor for oversedation and consider a lower diazepam dose while nilotinib is taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Diazepam with Nilotinib?
MediHelp rates the interaction as moderate. Diazepam and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may raise diazepam concentrations, causing increased or prolonged sedation. Nilotinib also prolongs the QT interval, but this is not directly affected by diazepam.
How serious is the interaction between Diazepam and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider a lower diazepam dose while nilotinib is taken.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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