Drug interactions
Diazepam + Orlistat
Severity: Minor
Diazepam and Orlistat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat reduces fat absorption and may lower the absorption of lipophilic drugs, and a reduced effect of anticonvulsants has been reported. The effect on diazepam is theoretical and not well documented, but loss of seizure control would matter in epilepsy patients.
What this interaction means in plain words
Diazepam and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Orlistat belongs to Miscellaneous.
Why it happens
Possible reduced gastrointestinal absorption of lipophilic diazepam due to orlistat's lipase inhibition and reduced dietary fat uptake.
What to do
Monitor clinical response, especially in patients using diazepam for seizure control, and consider separating doses by a few hours.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Orlistat
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
Frequently asked questions
Can I take Diazepam with Orlistat?
MediHelp rates the interaction as minor. Diazepam and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orlistat reduces fat absorption and may lower the absorption of lipophilic drugs, and a reduced effect of anticonvulsants has been reported. The effect on diazepam is theoretical and not well documented, but loss of seizure control would matter in epilepsy patients.
How serious is the interaction between Diazepam and Orlistat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response, especially in patients using diazepam for seizure control, and consider separating doses by a few hours.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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