Drug interactions
Diazepam + Propranolol
Severity: Minor
Diazepam and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol has been reported to slightly reduce diazepam clearance in some studies, but the clinical effect is small. Both drugs can cause drowsiness and dizziness.
What this interaction means in plain words
Diazepam and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Propranolol belongs to Cardiovascular.
Why it happens
Possible modest reduction of hepatic diazepam metabolism by propranolol.
What to do
No routine adjustment is needed; watch for excess sedation and reduce the diazepam dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Diazepam with Propranolol?
MediHelp rates the interaction as minor. Diazepam and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol has been reported to slightly reduce diazepam clearance in some studies, but the clinical effect is small. Both drugs can cause drowsiness and dizziness.
How serious is the interaction between Diazepam and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for excess sedation and reduce the diazepam dose if it occurs.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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