Drug interactions
Diazepam + Rufinamide
Severity: Minor
Diazepam and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak inducer of CYP3A4 and may modestly increase the clearance of diazepam's CYP3A4-dependent metabolism. This could slightly reduce diazepam exposure and its anxiolytic or anticonvulsant effect. The clinical impact is usually small.
What this interaction means in plain words
Diazepam and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by rufinamide increases the metabolism of diazepam.
What to do
Monitor seizure control or anxiolytic response when rufinamide is started or stopped. Adjust the diazepam dose only if efficacy is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Diazepam with Rufinamide?
MediHelp rates the interaction as minor. Diazepam and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak inducer of CYP3A4 and may modestly increase the clearance of diazepam's CYP3A4-dependent metabolism. This could slightly reduce diazepam exposure and its anxiolytic or anticonvulsant effect. The clinical impact is usually small.
How serious is the interaction between Diazepam and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control or anxiolytic response when rufinamide is started or stopped. Adjust the diazepam dose only if efficacy is reduced.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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