Drug interactions
Diazepam + Suvorexant
Severity: Moderate
Diazepam and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is an orexin receptor antagonist and diazepam is a benzodiazepine, so combining them adds to sedation and impairs psychomotor performance and next-day alertness. Falls and accidents are a concern, especially in older adults.
What this interaction means in plain words
Diazepam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression through different pathways (orexin antagonism and GABA-A potentiation).
What to do
Avoid routine co-use for insomnia and use the lowest effective doses if both are required. Counsel the patient about daytime impairment and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Suvorexant
Frequently asked questions
Can I take Diazepam with Suvorexant?
MediHelp rates the interaction as moderate. Diazepam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant is an orexin receptor antagonist and diazepam is a benzodiazepine, so combining them adds to sedation and impairs psychomotor performance and next-day alertness. Falls and accidents are a concern, especially in older adults.
How serious is the interaction between Diazepam and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-use for insomnia and use the lowest effective doses if both are required. Counsel the patient about daytime impairment and driving.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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