Drug interactions
Diazepam + Zuranolone
Severity: Moderate
Diazepam and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving. With diazepam, CNS depression and psychomotor impairment are increased.
What this interaction means in plain words
Diazepam and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Zuranolone belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor positive modulation causing CNS depression.
What to do
Consider reducing the zuranolone dose if sedation occurs. Counsel patients not to drive for at least 12 hours after each dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Diazepam with Zuranolone?
MediHelp rates the interaction as moderate. Diazepam and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving. With diazepam, CNS depression and psychomotor impairment are increased.
How serious is the interaction between Diazepam and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if sedation occurs. Counsel patients not to drive for at least 12 hours after each dose.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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