Drug interactions
Diazepam intranasal + Eszopiclone
Severity: Major
Diazepam intranasal and Eszopiclone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with a sedative-hypnotic can deepen sedation and impair respiratory drive and psychomotor function. The risk is greater in older adults, in patients with respiratory disease and with other CNS depressants.
What this interaction means in plain words
Diazepam intranasal and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor-mediated CNS depression.
What to do
Avoid routine concurrent use where possible; if both are required, use the lowest effective doses and monitor sedation and respiratory status. Do not give eszopiclone soon after a rescue diazepam dose without observation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eszopiclone
Frequently asked questions
Can I take Diazepam intranasal with Eszopiclone?
MediHelp rates the interaction as major. Diazepam intranasal and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with a sedative-hypnotic can deepen sedation and impair respiratory drive and psychomotor function. The risk is greater in older adults, in patients with respiratory disease and with other CNS depressants.
How serious is the interaction between Diazepam intranasal and Eszopiclone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use where possible; if both are required, use the lowest effective doses and monitor sedation and respiratory status. Do not give eszopiclone soon after a rescue diazepam dose without observation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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