Drug interactions
Diazepam intranasal + Fluoxetine
Severity: Moderate
Diazepam intranasal and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine inhibits CYP2C19, which helps clear diazepam, so diazepam levels and duration of effect may increase. The CNS depressant effects of the two drugs also add together, causing drowsiness and impaired coordination.
What this interaction means in plain words
Diazepam intranasal and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2C19 inhibition by fluoxetine and norfluoxetine reducing diazepam clearance, with additive CNS depression.
What to do
Monitor for excessive sedation and psychomotor impairment, and lower diazepam doses if needed. Warn patients about driving and other hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Fluoxetine?
MediHelp rates the interaction as moderate. Diazepam intranasal and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine inhibits CYP2C19, which helps clear diazepam, so diazepam levels and duration of effect may increase. The CNS depressant effects of the two drugs also add together, causing drowsiness and impaired coordination.
How serious is the interaction between Diazepam intranasal and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and psychomotor impairment, and lower diazepam doses if needed. Warn patients about driving and other hazardous tasks.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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