Drug interactions
Diazepam intranasal + Maprotiline
Severity: Moderate
Diazepam intranasal and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam and maprotiline both depress the CNS, so together they can cause greater sedation, impaired coordination and, rarely, respiratory depression. Maprotiline also lowers the seizure threshold, which may reduce the benefit of diazepam in seizure treatment.
What this interaction means in plain words
Diazepam intranasal and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and antidepressant sedative effects.
What to do
Monitor for oversedation and respiratory depression after dosing and counsel patients about driving. Ensure caregivers know to watch for excessive drowsiness after rescue doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Maprotiline?
MediHelp rates the interaction as moderate. Diazepam intranasal and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam and maprotiline both depress the CNS, so together they can cause greater sedation, impaired coordination and, rarely, respiratory depression. Maprotiline also lowers the seizure threshold, which may reduce the benefit of diazepam in seizure treatment.
How serious is the interaction between Diazepam intranasal and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression after dosing and counsel patients about driving. Ensure caregivers know to watch for excessive drowsiness after rescue doses.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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